Semaglutide Titration Schedule (Week by Week)
Dose progression reference for tracking your phase
4 min readQuick Answer:
Standard semaglutide titration starts at 0.25mg weekly for 4 weeks, then increases to 0.5mg for 4 weeks, then 1mg. Further increases to 1.7mg and 2.4mg are available if tolerated. Each phase lasts 4 weeks minimum before increasing.
Standard Titration Schedule
| Phase | Weeks | Weekly Dose | Purpose |
|---|---|---|---|
| 1 | 1-4 | 0.25mg | Initiation (GI tolerance) |
| 2 | 5-8 | 0.5mg | Therapeutic onset |
| 3 | 9-12 | 1.0mg | Full therapeutic dose |
| 4 | 13-16 | 1.7mg | Higher dose (if needed) |
| 5 | 17+ | 2.4mg | Maximum dose |
Titer tracks your titration phase automatically.
Set your schedule. Get reminded when the dose changes.
Units to Draw (5mg/2ml Reconstitution)
If you reconstituted 5mg semaglutide in 2ml BAC water (2.5mg/ml):
| Dose | Volume | U-100 Units | Injections per Vial |
|---|---|---|---|
| 0.25mg | 0.1ml | 10 units | 20 |
| 0.5mg | 0.2ml | 20 units | 10 |
| 1.0mg | 0.4ml | 40 units | 5 |
| 1.7mg | 0.68ml | 68 units | 2.9 |
| 2.4mg | 0.96ml | 96 units | 2.1 |
Why Tracking Phase Matters
- Dose changes every 4 weeks - You need to know which week you're on
- Side effects inform progression - Nausea at 0.5mg? Stay there longer before increasing
- Inventory planning - A 5mg vial lasts 20 weeks at 0.25mg but only 5 weeks at 1mg
- Stacking with other compounds - Your semaglutide schedule overlaps with your other protocols
When to Delay Dose Increase
- Significant nausea lasting more than a few days at current dose
- GI symptoms (constipation, diarrhea) not resolved
- Current dose is producing desired results
- Combination with other compounds creating side effects
Stay at the current dose until side effects resolve, then consider increasing. There's no requirement to reach maximum dose.
Related Questions
- How to calculate peptide dose after reconstitution
- How many doses in a peptide vial?
- How to track 5/2 cycling schedules
Titer tracks titration phases automatically.
Set your schedule. It reminds you when the dose changes.
See Plans & PricingDisclaimer: This is a reference schedule, not medical advice. Titration decisions should be made with a healthcare provider.